Synovial fibroblast activation occurs before the onset of rheumatoid arthritis and influences the risk of developing disease
The findings in this small RA-at-risk cohort suggest that synovial fibroblast activation occurs early in the disease process of RA and is associated with an increased risk for clinical RA onset. These results warrant further research on FAPI-PET-CT to improve risk assessment for clinical RA onset.
Authors
- Armin Atzinger
- Axel J. Hueber (ORCID: https://orcid.org/0000-0001-6454-1234)
- Arnd Kleyer (ORCID: https://orcid.org/0000-0002-2026-7728)
- Christian Schmidkonz (ORCID: https://orcid.org/0000-0002-1988-0058)
- Koray Taşçılar (ORCID: https://orcid.org/0000-0002-8109-826X)
- Giulia Corte (ORCID: https://orcid.org/0009-0007-2218-6503)
- Andreas Ramming (ORCID: https://orcid.org/0000-0002-7003-501X)
- Torsten Kuwert (ORCID: https://orcid.org/0000-0001-5682-8139)
- Filippo Fagni (ORCID: https://orcid.org/0000-0002-6122-0774)
- Sara Bayat (ORCID: https://orcid.org/0000-0002-2799-184X)
- Michael Beck (ORCID: https://orcid.org/0000-0003-2523-6266)
- G. Schett
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Paracelsus Medical University (AT)
- Ostbayerische Technische Hochschule Amberg-Weiden (DE)
- Paracelsus Medizinische Privatuniversität (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- RMD Open
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/rmdopen-2025-005775
- Citations
- 2
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Staedtler Stiftung
- Leibniz-Gemeinschaft