Identification of individuals at high risk of developing rheumatoid arthritis: a balanced random forest model in a cohort of 1544 first-degree relatives
Overall, the results demonstrate that predicting RA by combining genetics, serological biomarkers, epidemiological risk factors and clinical signs is promising, although model generalisation remains challenging. The low prevalence of RA in the cohort complicates the development of highly accurate prediction models. Future efforts should focus on including external validation and potentially incorporating additional biomarkers to enhance the sensitivity and overall performance of the predictive tests.
Authors
- Benoît Gilbert (ORCID: https://orcid.org/0000-0001-6037-6470)
- David Spoerl (ORCID: https://orcid.org/0000-0002-2575-9537)
- Isabel Gehring (ORCID: https://orcid.org/0000-0002-2516-5261)
- Andrea Rubbert‐Roth (ORCID: https://orcid.org/0000-0002-9016-2833)
- Axel Finckh (ORCID: https://orcid.org/0000-0002-1210-4347)
- Ines von Mühlenen
- Diego Kyburz (ORCID: https://orcid.org/0000-0002-9560-109X)
- Delphine Sophie Courvoisier (ORCID: https://orcid.org/0000-0002-1956-2607)
- Adrian Ciurea (ORCID: https://orcid.org/0000-0002-7870-7132)
- Sascha Swiniarski
- Céline Lamacchia (ORCID: https://orcid.org/0000-0002-0291-8865)
- Laure Brulhart (ORCID: https://orcid.org/0000-0001-6347-720X)
- Olivia Studer
- Diana Dan (ORCID: https://orcid.org/0000-0003-1749-3238)
- Jean Dudler (ORCID: https://orcid.org/0000-0001-8533-5800)
- Maresa Grundhuber
- Romain Guemara (ORCID: https://orcid.org/0000-0001-7776-4533)
- Burkhard Möller (ORCID: https://orcid.org/0000-0001-8769-6167)
- Zübeyir Salis (ORCID: https://orcid.org/0000-0003-2982-4591)
- Romain Aymon (ORCID: https://orcid.org/0000-0003-2854-3632)
- Ruediger B. Müeller
Institutions
- University of Geneva (CH)
- Université de Montpellier (FR)
- University of Zurich (CH)
- Kantonsspital St. Gallen (CH)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
- Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR)
- University Hospital of Zurich (CH)
- International Museum of Horology (CH)
- Department of Biomedicine Basel (CH)
- Thermo Fisher Scientific (Germany) (DE)
- Ostschweizer Kinderspital (CH)
- Geneva College (US)
- University of Lausanne (CH)
Publication Details
- Journal
- RMD Open
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/rmdopen-2025-005773
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00