Quantitative proteomic analysis of pathological and physiological ovarian aging: model evaluation, molecular mechanisms, and identification of early biomarkers and therapeutic targets
This study confirmed the validity of the cyclophosphamide-busulfan induced mouse model of ovarian senescence, highlighted both the shared and distinct molecular mechanisms of physiological and pathological ovarian aging, and identified promising early biomarkers and therapeutic intervention targets.
Authors
- Yuehui Zheng (ORCID: https://orcid.org/0000-0002-2345-7893)
- Shuyi Ling
- Ruoxin Weng
- Wenbo Wu (ORCID: https://orcid.org/0000-0002-7642-9773)
- Yuan Li (ORCID: https://orcid.org/0000-0001-5651-819X)
- Mengying Bai
- Liujuan Zhang
- Haifeng Wu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13048-025-01874-1
- Citations
- 2
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- National Natural Science Foundation of China
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Guangzhou University