Advances in the characterization of in vitro–generated red blood cells: from biophysical properties to functional applications

This review underscores both current advances and persistent challenges in characterizing in vitro-generated RBCs, and it proposes a translational framework that integrates multi-omics data into their development and evaluation. By explicitly linking molecular regulation with process control and quality metrics, this approach provides a roadmap to optimize functional performance and ensure clinical readiness of in vitro-generated RBCs.

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Publication Details

Journal
Stem Cell Research & Therapy
Published
2025-11-28
DOI
https://doi.org/10.1186/s13287-025-04825-1
Primary Topic
Erythrocyte Function and Pathophysiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Advances in the characterization of in vitro–generated red blood cells: from biophysical properties to functional applications

Ye-Ji Jang, Justine Han, Seung-Hee Gwak, Young Woo Eom et al.
Stem Cell Research & Therapy
Erythrocyte Function and Pathophysiology
article

Advances in the characterization of in vitro–generated red blood cells: from biophysical properties to functional applications

Ye-Ji Jang, Justine Han, Seung-Hee Gwak, Young Woo Eom, Yoojun Nam, Yoon Seok Koh, Yeri Alice Rim, Ji Hyeon Ju
article en

Abstract

This review underscores both current advances and persistent challenges in characterizing in vitro-generated RBCs, and it proposes a translational framework that integrates multi-omics data into their development and evaluation. By explicitly linking molecular regulation with process control and quality metrics, this approach provides a roadmap to optimize functional performance and ensure clinical readiness of in vitro-generated RBCs.

Stem Cell Research & TherapyVol. 17(1)
LG (United States) (US), The Catholic University of Korea Seoul St. Mary's Hospital (KR), Sungkyunkwan University (KR), Catholic University of Korea (KR)
Openalex Percentile: Top 54%
Erythrocyte Function and Pathophysiology
DOIOpen Access PDFOpenAlex
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Advances in the characterization of in vitro–generated red blood cells: from biophysical properties to functional applications — Ye-Ji Jang, Justine Han, et al. · Stem Cell Research & Therapy (2025) | TGRS Research Map | TGRS