Targeted proteomics reveal α-MSH-like Enterobacterial ClpB protein in gut microbiota of patients with anorexia nervosa
α-melanocyte-stimulating hormone (α-MSH) is an anorexigenic peptide. In this exploratory study, a targeted proteomic approach was used to detect α-MSH-like bacterial proteins in the gut microbiota of patients with anorexia nervosa (AN) and healthy controls. Enterobacteriaceae chaperone DnaK was identified as an α-MSH-like protein common to both study groups, while caseinolytic protease B (ClpB) was present in patients with AN. These data further link anorexigenic ClpB to the AN pathophysiology.
Authors
- Sergueı̈ O. Fetissov (ORCID: https://orcid.org/0000-0002-2491-4945)
- Beate Herpertz‐Dahlmann (ORCID: https://orcid.org/0000-0001-8450-3323)
- Mohamed Amine Ben Mlouka
- Emilie Lahaye (ORCID: https://orcid.org/0000-0002-5785-5785)
- Jochen Seitz (ORCID: https://orcid.org/0000-0002-0110-7980)
- Lisa Wallart (ORCID: https://orcid.org/0009-0001-3788-0115)
- Lisa Brémard (ORCID: https://orcid.org/0009-0006-5367-844X)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Différenciation et Communication Neuronale et Neuroendocrine (FR)
- Klinik für Psychosomatik (DE)
- Université de Rouen Normandie (FR)
- RWTH Aachen University (DE)
Publication Details
- Journal
- npj Biofilms and Microbiomes
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1038/s41522-025-00850-3
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Bundesministerium für Bildung und Forschung
- Région Normandie