A Case of Metastatic Spinal Cord Compression in a Patient With Coexisting Chronic Lymphocytic Leukemia and Colon Cancer

A 78-year-old patient with a known diagnosis of colorectal cancer and chronic lymphocytic leukemia (CLL) presented to the emergency department with progressive neurological symptoms and was found to have metastatic spinal cord compression (MSCC) on MRI. A CT-guided biopsy of the affected vertebral bodies confirmed the bone lesions to be of CLL origin, not colorectal. The patient was treated with radiotherapy and commenced on acalabrutinib, a tyrosine kinase inhibitor. This case highlights the diagnostic and therapeutic considerations in managing spinal disease in a patient with coexisting hematological and solid organ malignancy. Multidisciplinary evaluation, timely biopsy, and individualized therapy are crucial in guiding treatment decisions for spinal cord compression in patients with dual malignancies.