C3G deregulation uncovers a dual role in B-cell lymphoma: tumor suppression and enhanced metastasis via Rap1 and Rac2 signaling
C3G plays a dual role in B-cell lymphoma: it acts as a tumor suppressor by inhibiting growth and promoting apoptosis, but may also facilitate metastasis via enhanced motility. This dual effect likely reflects a functional balance between Rap1 and Rac2 signaling. These findings underscore the complexity of C3G-regulated pathways in B cells and suggest that C3G may serve as a potential novel marker in hematologic malignancies.
Authors
- Coert Margadant (ORCID: https://orcid.org/0000-0002-5957-6683)
- Cristina Fernández‐Infante
- Alba Morán-Vaquero (ORCID: https://orcid.org/0000-0002-9887-1538)
- Carmen Guerrero (ORCID: https://orcid.org/0000-0002-8747-6831)
- Elena Vuelta (ORCID: https://orcid.org/0000-0002-3289-0605)
- Ignacio García‐Tuñón (ORCID: https://orcid.org/0000-0003-4758-2151)
- Antonio Rodríguez-Blázquez (ORCID: https://orcid.org/0000-0002-7534-4196)
- Óscar Herranz (ORCID: https://orcid.org/0000-0002-1136-7436)
- José M. de Pereda (ORCID: https://orcid.org/0000-0002-8912-6739)
- Femke van der Meer
- Ana Dávila-Hidalgo
Institutions
- Leiden University (NL)
- Universidad de Salamanca (ES)
- Universidad de Alcalá (ES)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Centro de Investigación del Cáncer (ES)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s12964-025-02551-y
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00