Exploring the interconnections between baseline symptoms in ultra-high risk youth who did and did not transition to psychosis over three years: A network analysis comparison
The networks of youth who transitioned and who did not transition were similar, indicating similar baseline symptom relationships. Across groups, unusual thought content, despite being traditionally associated with transition, had little to no interactions with other symptoms. Clinical manifestations that may need attention include impaired cognitive functioning, which connected several symptoms, and impaired bodily sensation. Future research using time series data may support progress toward individualized care.
Authors
- Tommaso Boldrini (ORCID: https://orcid.org/0000-0003-3381-9445)
- Ashleigh Peng Lin (ORCID: https://orcid.org/0000-0002-4054-0242)
- Jessica Hartmann (ORCID: https://orcid.org/0000-0001-7662-6155)
- Stephen James Wood (ORCID: https://orcid.org/0000-0003-4186-5919)
- Dominic Dwyer (ORCID: https://orcid.org/0000-0003-3949-5867)
- Andrew David Thompson (ORCID: https://orcid.org/0000-0002-0567-6013)
- Andrea Polari (ORCID: https://orcid.org/0000-0002-0680-3192)
- Suzie Lavoie (ORCID: https://orcid.org/0000-0001-8372-2399)
- Scott Richard Clark (ORCID: https://orcid.org/0000-0003-1640-5611)
- Isabelle Scott (ORCID: https://orcid.org/0000-0001-8293-6125)
- Barnaby Nelson (ORCID: https://orcid.org/0000-0002-6263-2332)
- Patrick D. McGorry (ORCID: https://orcid.org/0000-0002-3789-6168)
- Annalisa Tanzilli (ORCID: https://orcid.org/0000-0002-6098-2304)
- Josh Nguyen (ORCID: https://orcid.org/0000-0002-9106-0388)
- Vittorio Lingiardi (ORCID: https://orcid.org/0000-0002-1298-3935)
- Gabriele Lo Buglio (ORCID: https://orcid.org/0000-0003-2425-8383)
- Hok Pan Yuen (ORCID: https://orcid.org/0000-0002-1237-1322)
- Simon Hartmann (ORCID: https://orcid.org/0000-0001-9689-0594)
- Alison Ruth Yung (ORCID: https://orcid.org/0000-0002-0401-9791)
- Cassandra M. J. Wannan (ORCID: https://orcid.org/0000-0003-1317-4635)
Institutions
- Deakin University (AU)
- University of Ottawa (CA)
- The University of Melbourne (AU)
- The University of Western Australia (AU)
- Heidelberg University (DE)
- Ottawa Hospital (CA)
- University Hospital Heidelberg (DE)
- University of Manchester (GB)
- Central Institute of Mental Health (DE)
- Orygen (AU)
- Pegaso University (IT)
- Ottawa Hospital Research Institute (CA)
- The University of Adelaide (AU)
- Swinburne University of Technology (AU)
- University of Birmingham (GB)
- Heidelberg University (US)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- European Psychiatry
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1192/j.eurpsy.2025.10141
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- University of Cambridge
- H. Lundbeck A/S
- Medical Research Council
- National Health and Medical Research Council
- National Institute of Mental Health
- Cilag