Dose-Dependent Ferroptosis Induction in Osteosarcoma via NRF2/GPX4 Axis Modulation by Plasma-Activated Liquid Therapy
High-dose PAL-induced sustained oxidative stress by simultaneously targeting NRF2 inactivation and GPX4 degradation, establishing redox imbalance as a critical ferroptotic checkpoint in OS therapy. <i>Antioxid. Redox Signal.</i> 44, 292-310.
Authors
- Shenglin Xu
- Peng He (ORCID: https://orcid.org/0000-0002-0378-0300)
- Sheng Li (ORCID: https://orcid.org/0000-0002-9073-6809)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Mian Zhang (ORCID: https://orcid.org/0000-0001-9838-3895)
- Yong Hu (ORCID: https://orcid.org/0000-0001-7562-4502)
- Yonghong Wu (ORCID: https://orcid.org/0009-0005-8032-9985)
- Longze Xiao
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Antioxidants and Redox Signaling
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1177/15230864251399168
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52