A prospective cohort study on progestin-primed ovarian stimulation vs. GnRH antagonist in IVF-ICSI cycles: effects on clinical pregnancy and neonatal outcomes

This prospective cohort study observed patients undergoing IVF/ICSI treatment with either the PPOS or GnRH antagonist protocols, ensuring a fair comparison. PSM and IPTW were used to balance baseline characteristics and adjust for remaining differences, thereby improving the reliability of the results. A key strength lies in the large matched sample, which enhances statistical power. Additionally, unlike previous studies, this research included neonatal outcomes, offering a more comprehensive evaluation of both pregnancy success and infant health. The combination of advanced statistical methods and a focus on long-term outcomes renders this study a significant contribution to the field of infertility treatment.