Parent-of-origin effects of phosphatidyl inositol-bisphosphate hydrolysis pathway genes on type 2 diabetes and the modification effect by obesity
The current study provides a preliminary hint that SNPs in the PIP2 pathway genes may exhibit POE on T2D, contributing to its heritability. Notably, five SNPs in the <i>PRKCQ</i> gene demonstrated a potential interaction between POE and BMI on T2D. Further research is necessary to explore the underlying molecular mechanisms and to validate these findings in larger and independent populations.
Authors
- Yinxi Tan (ORCID: https://orcid.org/0000-0002-7118-085X)
- Mengying Wang (ORCID: https://orcid.org/0000-0002-2609-9454)
- Yiqun Wu (ORCID: https://orcid.org/0000-0002-5554-1678)
- Siyue Wang (ORCID: https://orcid.org/0000-0002-0186-7955)
- Huangda Guo (ORCID: https://orcid.org/0000-0003-2973-7711)
- Dafang Chen (ORCID: https://orcid.org/0000-0001-8226-5413)
- Ping Hu (ORCID: https://orcid.org/0000-0001-6770-4190)
- Yixin Li (ORCID: https://orcid.org/0000-0003-1074-6239)
- Haodong Zhang (ORCID: https://orcid.org/0009-0007-4568-6180)
- Yi Zheng (ORCID: https://orcid.org/0009-0009-8143-7813)
- Jing Li (ORCID: https://orcid.org/0000-0002-8840-8638)
- Xueying Qin (ORCID: https://orcid.org/0000-0003-3271-8618)
- Yonghua Hu (ORCID: https://orcid.org/0000-0003-1631-3952)
- Tao Wu (ORCID: https://orcid.org/0000-0001-9456-4082)
- Hexiang Peng
- Hanyu Zhang (ORCID: https://orcid.org/0000-0003-2259-1721)
Institutions
- Central South University (CN)
- Peking University (CN)
- Ministry of Education (RO)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fendo.2025.1705584
- Primary Topic
- Protein Kinase Regulation and GTPase Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China