THRA Orchestrates Myocardial Protection Against Hypothyroidism-Induced Ferroptosis <i>via</i> the GATA4-GPX4 Transcriptional Cascade

This study defines the <i>GATA4</i>-<i>THRA</i>-<i>GPX4</i> transcriptional axis as a crucial mechanism that protects the heart from hypothyroidism-driven ferroptosis, uncovering a previously unrecognized transcriptional axis that is crucial for cardioprotection during hypothyroidism. <i>Antioxid. Redox Signal.</i> 44, 236-250.

Authors

Institutions

Publication Details

Journal
Antioxidants and Redox Signaling
Published
2025-11-26
DOI
https://doi.org/10.1177/15230864251399166
Citations
1
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
1.52
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

THRA Orchestrates Myocardial Protection Against Hypothyroidism-Induced Ferroptosis via the GATA4-GPX4 Transcriptional Cascade

Xianen Fa, Zhang Runfang
1 citations
Antioxidants and Redox Signaling
Ferroptosis and cancer prognosis
1.52
article

THRA Orchestrates Myocardial Protection Against Hypothyroidism-Induced Ferroptosis via the GATA4-GPX4 Transcriptional Cascade

Xianen Fa, Zhang Runfang
article en
1 citations

Abstract

This study defines the <i>GATA4</i>-<i>THRA</i>-<i>GPX4</i> transcriptional axis as a crucial mechanism that protects the heart from hypothyroidism-driven ferroptosis, uncovering a previously unrecognized transcriptional axis that is crucial for cardioprotection during hypothyroidism. <i>Antioxid. Redox Signal.</i> 44, 236-250.

Antioxidants and Redox SignalingVol. 44(4-6)
Second Affiliated Hospital of Zhengzhou University (CN)
Openalex Percentile: Top 12%
Ferroptosis and cancer prognosis
1.52
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.