Comprehensive molecular profiling of urologic tumors presented in a molecular tumor board: insights from a real-world precision oncology cohort
Comprehensive molecular profiling in a MTB setting reveals distinct and therapeutically relevant mutational patterns across urologic cancers. These data support the integration of MTBs into clinical workflows and highlight the potential of co-mutational signatures to guide personalized treatment strategies.
Authors
- Silke Laßmann
- Julia Kühn (ORCID: https://orcid.org/0000-0002-8038-7246)
- Christian Gratzke (ORCID: https://orcid.org/0000-0003-4070-0952)
- Heiko Becker (ORCID: https://orcid.org/0000-0002-6919-4048)
- August Sigle (ORCID: https://orcid.org/0000-0001-6857-8149)
- Ruth Himmelsbach (ORCID: https://orcid.org/0009-0001-2178-5586)
- Markus Grabbert (ORCID: https://orcid.org/0000-0002-7059-6124)
- Melanie Börries
- Maximilian Glienke (ORCID: https://orcid.org/0000-0002-6051-4404)
- Cathleen Nientiedt (ORCID: https://orcid.org/0000-0001-5970-5951)
- Martin Werner (ORCID: https://orcid.org/0000-0002-6951-8022)
- Cornelius Miething (ORCID: https://orcid.org/0000-0003-4699-3805)
- Michael Rassner (ORCID: https://orcid.org/0000-0003-0964-9511)
- Patrick Metzger (ORCID: https://orcid.org/0000-0002-2451-1943)
- Justus Duyster (ORCID: https://orcid.org/0000-0001-7325-7753)
- Max Zirngibl
Institutions
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fonc.2025.1688779
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00