Single-cell transcriptomics reveals immune remodeling of the murine lung microenvironment following chronic house dust mite exposure
These findings demonstrate that chronic HDM exposure profoundly remodels the lung immune microenvironment through IL-1β-dependent and -independent mechanisms. The effects are context-dependent and modulated by the endotoxin content of HDM extracts, highlighting the complex immunomodulatory effects of HDM in inducing chronic lung inflammation.
Authors
- Nicholas J. G. Webster (ORCID: https://orcid.org/0000-0002-3827-5750)
- Samuel Bertin (ORCID: https://orcid.org/0000-0003-2340-959X)
- Kathleen M. Fisch (ORCID: https://orcid.org/0000-0002-0117-7444)
- Scott Herdman (ORCID: https://orcid.org/0000-0002-0792-9360)
- Chanond A. Nasamran
- Maripat Corr
- Zahra Malakoutikhah (ORCID: https://orcid.org/0000-0002-9930-6442)
- Eyal Raz (ORCID: https://orcid.org/0009-0001-2146-2963)
- Liping Zeng (ORCID: https://orcid.org/0000-0001-7115-6836)
- Han Chang (ORCID: https://orcid.org/0000-0002-8479-3591)
Institutions
- University of California System (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1652539
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16