Lactate-Induced Lipid Accumulation in Hepatocytes through GPR81 Activation
Our findings demonstrate that lactate promotes hepatic steatosis primarily via the GPR81-AMPK signaling axis. GPR81 activation enhances lipogenesis and lipid uptake, independent of MCT1-mediated transport. These results position GPR81 as a promising therapeutic target for NAFLD.
Authors
- Jeana Hong (ORCID: https://orcid.org/0000-0003-0332-7466)
- Seung‐Soon Im (ORCID: https://orcid.org/0000-0002-2743-2108)
- Ji Hee Yu (ORCID: https://orcid.org/0000-0003-1907-2859)
- Giang Nguyen (ORCID: https://orcid.org/0000-0001-9269-262X)
- Dae Hee Choi (ORCID: https://orcid.org/0000-0002-8956-7518)
- Seon Mee Kang (ORCID: https://orcid.org/0000-0002-4056-7525)
- Ki Woo Kim (ORCID: https://orcid.org/0000-0002-7790-1515)
- Eun-Hee Cho (ORCID: https://orcid.org/0000-0002-1349-8894)
- Jae‐Ho Lee (ORCID: https://orcid.org/0000-0003-2619-1231)
- So Young Park (ORCID: https://orcid.org/0000-0002-8625-6968)
- Yong‐ho Lee (ORCID: https://orcid.org/0000-0002-6219-4942)
- Tin Pou Lai
- Phuc Nguyen Huu Pham
Institutions
- Kangwon National University (KR)
- Gyeongsang National University (KR)
- Yonsei University (KR)
- Korea University (KR)
- Yonsei University College of Dentistry
- Keimyung University (KR)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2025-11-27
- DOI
- https://doi.org/10.4093/dmj.2024.0531
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00