M1 macrophage-derived exosomal miR-20b promotes radiosensitization via CCND1 in HPV+ HNSCC
In this study, our results suggest that M1 exos, enriched with miR-20b, regulate the DNA damage repair pathway in tumor cells by targeting CCND1, enhancing the radiosensitivity of HPV<sup>+</sup> HNSCC.
Authors
- Shuang Pan (ORCID: https://orcid.org/0000-0002-5087-3737)
- Siyu Duan
- Zengchen Liu (ORCID: https://orcid.org/0009-0000-4677-2127)
- Tao Gong (ORCID: https://orcid.org/0000-0001-6885-6962)
- Huan Liu (ORCID: https://orcid.org/0000-0002-2676-6982)
- Tianyang Liu (ORCID: https://orcid.org/0000-0003-2598-8572)
- Siwei Zhang (ORCID: https://orcid.org/0009-0005-0873-5217)
- Wanlin Li (ORCID: https://orcid.org/0000-0002-8538-8571)
- Lanlan Wei
- Fangjia Tong
Institutions
- Northwestern University (US)
- Harbin Medical University (CN)
- Southern University of Science and Technology (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fonc.2025.1693487
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00