Gallic acid alleviates visceral hyperalgesia following maternal separation in mice by inhibiting EphrinB2/EphB2 signaling mediated activation of neurons and glial cells
Our findings suggest that spinal EphrinB2/EphB2 signaling is crucial in the development of maternal separation-induced visceral hyperalgesia. GA may alleviate hyperalgesia by inhibiting the EphrinB2/EphB2 signaling pathway, thereby modulating nociceptive processing by MS.
Authors
- Jiaping Ruan
- Wei Zhang (ORCID: https://orcid.org/0000-0002-5111-4097)
- Shufen Guo
- Han Zheng (ORCID: https://orcid.org/0000-0002-7644-5634)
- Dan Li (ORCID: https://orcid.org/0000-0002-5586-4055)
- Yu Wang (ORCID: https://orcid.org/0009-0005-9856-9979)
- Hong-qin Tu
- Zhengliang Ma (ORCID: https://orcid.org/0000-0002-1000-4123)
- Yaming Xi (ORCID: https://orcid.org/0009-0000-6868-7687)
Institutions
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1698744
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00