Antibiotic-induced gut microbiota depletion enhances glucose tolerance linked to GLP-1 signaling
Our findings suggest that the metabolic improvements following gut microbiota depletion are primarily driven by GLP-1 signaling, rather than UCP1⁺ cell activation. These results highlight the complex interplay between the gut microbiome and metabolic health, offering insights into potential therapeutic targets for improving glucose metabolism through modulation of basal GLP-1 signaling.
Authors
- Alice de Wouters d’Oplinter (ORCID: https://orcid.org/0000-0002-9983-8828)
- Christian Wolfrum (ORCID: https://orcid.org/0000-0002-3862-6805)
- Andreas Sichert (ORCID: https://orcid.org/0000-0002-1386-5535)
- Alexandra Kellenberger
- Revati S. Dewal (ORCID: https://orcid.org/0000-0002-7765-8703)
- Emma Slack (ORCID: https://orcid.org/0000-0002-2473-1145)
- Tenagne D. Challa (ORCID: https://orcid.org/0000-0002-5898-8061)
- Markus Heine (ORCID: https://orcid.org/0000-0001-9761-8250)
- Marceline M. Fuh
Institutions
- Universität Hamburg (DE)
- ETH Zurich (CH)
- University Medical Center Hamburg-Eppendorf (DE)
- Nutrition Sciences (Belgium) (BE)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fendo.2025.1684155
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00