Therapy-induced remodeling of IgG and plasma N-glycans in breast cancer
IgG glycosylation patterns change in a treatment-specific manner during chemotherapy, potentially reflecting immune modulation. Plasma glycan traits are more stable but may reflect tumor burden. These results support the potential of glycan profiling as a biomarker for monitoring the impact of therapy and disease progression in breast cancer.
Authors
- Ivan Milas (ORCID: https://orcid.org/0000-0002-2083-1085)
- Dragan Primorac (ORCID: https://orcid.org/0000-0001-5565-080X)
- Mihaela Gaće (ORCID: https://orcid.org/0009-0004-5470-7850)
- Gordan Lauc (ORCID: https://orcid.org/0000-0003-1840-9560)
- David Visentin (ORCID: https://orcid.org/0009-0001-8502-3978)
- Iva Kirac (ORCID: https://orcid.org/0000-0002-6507-8875)
- Ivan Gudelj (ORCID: https://orcid.org/0000-0003-0624-7170)
- Boz̆o Trbojević
- Martina Maričić Vrban
- Katarina Ramljak
Institutions
- Lee College (US)
- Pennsylvania State University (US)
- National Forensic Sciences University (IN)
- University Hospital Centre Zagreb (HR)
- University of Rijeka (HR)
- University of Zagreb (HR)
- University of New Haven (US)
- Sana Kliniken Duisburg (DE)
- Catholic University of Croatia (HR)
- Genos (Croatia) (HR)
- Science Research Laboratory (US)
- University of Osijek (HR)
- University of Split (HR)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s12885-025-15381-5
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00