The interaction between the gene SOD1 rs2070424 and the plasma zinc/copper ratio predicts renal function impairment
Decline in renal function was positively correlated with plasma zinc and the zinc/copper ratio and negatively correlated with plasma copper. The relationship between impaired renal function and both zinc and the zinc/copper ratio was modified by rs2070424 genotypes. Taken together, considering zinc/copper ratio provides a more informative summary than single-metal measures and shows partial incremental discrimination.
Authors
- Li‐Qiang Qin (ORCID: https://orcid.org/0000-0002-5231-2562)
- Xiaoyan Qian (ORCID: https://orcid.org/0000-0001-7509-8071)
- Jingsi Chen (ORCID: https://orcid.org/0000-0002-8438-6590)
- Jiayuan Song
- Xi‐Yu Wu (ORCID: https://orcid.org/0000-0002-4264-8388)
- Qiuguo Wang
- Tianci Wang (ORCID: https://orcid.org/0000-0002-3460-7818)
- Chang Zhou (ORCID: https://orcid.org/0000-0001-9796-9966)
- MA Yu-qin (ORCID: https://orcid.org/0009-0007-3122-5615)
- Senlin Zhu (ORCID: https://orcid.org/0000-0001-8975-6792)
- Jiaju Ge
- Hong‐Zhen Du
- Zengning Li
Institutions
- Hebei Medical University (CN)
- Soochow University (CN)
- Hebei Science and Technology Department (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fnut.2025.1716103
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Priority Academic Program Development of Jiangsu Higher Education Institutions