Shikimic acid attenuates oxidative stress-induced senescence in 3D4/21 cells by modulating PARP1 activity and DNA damage response
SA effectively restores homeostasis in oxidatively injured 3D4/21 cells by concurrently mitigating oxidative stress and inflammation, modulating the DDR, particularly PARP1 activation and associated factors, and attenuating cellular senescence. This positions SA as a promising candidate for further investigation as a therapeutic agent for human lung diseases characterized by macrophage dysfunction and oxidative pathology.
Authors
- Kaibin Mo (ORCID: https://orcid.org/0009-0005-2705-9939)
- Weichun Wu
- Yicheng Zhang (ORCID: https://orcid.org/0009-0009-6300-4213)
- Li Li (ORCID: https://orcid.org/0000-0003-2342-3658)
- Linlin Yang (ORCID: https://orcid.org/0000-0002-6119-5476)
- Huang XianHui (ORCID: https://orcid.org/0000-0002-0843-9873)
- Chengyu Wu
Institutions
- South China Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fnut.2025.1614148
- Primary Topic
- Mangiferin and Mango Extracts
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China