Determining Preclinical Safety of Aclarubicin in Pediatric Malignancies
Our study highlights Acla as a promising anthracycline derivative for pediatric cancers, with potent anti-tumor efficacy and a superior safety profile, even following prior anthracycline exposure. These results support continued investigation of chromatin-damaging anthracyclines that can kill pediatric cancer cells without inducing genotoxic stress. In addition, our studies underscore the need to refine preclinical models to better understand both acute and chronic anthracycline toxicities in pediatric and adolescent populations.
Authors
- Shireen Ganapathi (ORCID: https://orcid.org/0000-0002-1239-2166)
- Radhika A. Patel (ORCID: https://orcid.org/0009-0008-4889-6818)
- Erolcan Sayar (ORCID: https://orcid.org/0000-0002-3922-5683)
- Elizabeth R. Lawlor (ORCID: https://orcid.org/0000-0002-2350-1540)
- Lisa Maves (ORCID: https://orcid.org/0000-0002-9798-790X)
- Jenna R. Rosinski (ORCID: https://orcid.org/0000-0003-3709-2132)
- Kimberly S. Waggie (ORCID: https://orcid.org/0000-0002-1610-6024)
- Jay F. Sarthy (ORCID: https://orcid.org/0000-0001-5244-7865)
- Jacques Neefjes (ORCID: https://orcid.org/0000-0001-6763-2211)
- Michael C. Haffner (ORCID: https://orcid.org/0000-0003-0809-6425)
- Virginia J. Hoglund (ORCID: https://orcid.org/0000-0003-1175-5006)
- Aaron Olson (ORCID: https://orcid.org/0000-0002-5237-400X)
- Nicolas M. Garcia (ORCID: https://orcid.org/0000-0002-3717-5520)
- Stephanie Walter
- Darleen S. Tu
- Harini Sadeeshkumar
Institutions
- Seattle Children's Hospital (US)
- University of Washington (US)
- Leiden University Medical Center (NL)
- Fred Hutch Cancer Center (US)
- Oncode Institute (NL)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1002/pbc.32169
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- CURE Childhood Cancer
- University of Washington
- Seattle Children's Research Institute
- Sunbeam Foundation
- Children’s Hospital of Wisconsin Research Institute
- National Institutes of Health
- National Cancer Institute