Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice
These findings demonstrate that HCAR2 mediates β-hydroxybutyrate's antiseizure effects by regulating neuronal excitability and synaptic transmission. These studies propose a new mechanism for the antiseizure action of the ketogenic diet. ANN NEUROL 2026;99:809-824.
Authors
- Chengsan Sun (ORCID: https://orcid.org/0009-0002-6429-7846)
- Suchitra Joshi (ORCID: https://orcid.org/0000-0003-3524-2061)
- Ifrah Zawar (ORCID: https://orcid.org/0000-0002-6103-4250)
- John Williamson (ORCID: https://orcid.org/0000-0001-8169-1605)
- Supriya Sharma (ORCID: https://orcid.org/0000-0002-2050-368X)
- Huayu Sun (ORCID: https://orcid.org/0000-0002-6532-7018)
- Jaideep Kapur (ORCID: https://orcid.org/0000-0002-8608-1352)
- Soudabeh Naderi
- Rachel Jane Spera (ORCID: https://orcid.org/0009-0003-8729-2519)
- Andrey Brodovskiy
- Savaira Zaib
Institutions
- University of Virginia (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1002/ana.78098
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institute of Neurological Disorders and Stroke