Cumulative childhood lead exposure estimation and school-age IQ in a prospective birth cohort
We used a regression calibration method to leverage robust, repeated lead exposure data in our prospective pregnancy and birth cohort. In this cohort with low levels of lead exposure, cumulative childhood lead exposure estimate was negatively associated with school-age IQ in unadjusted analyses but not adjusted analyses. We considered sociodemographic and maternal factors previously associated with cognitive development. Our results suggest these factors may confound the association between low-level child lead exposure and child IQ.
Authors
- Kim M. Cecil (ORCID: https://orcid.org/0000-0001-8233-5485)
- Nicholas Newman (ORCID: https://orcid.org/0000-0003-1963-4006)
- Christopher D. Palmer (ORCID: https://orcid.org/0000-0002-6637-991X)
- Kimberly Yolton (ORCID: https://orcid.org/0000-0002-4458-0516)
- Melinda C. MacDougall (ORCID: https://orcid.org/0009-0005-5821-3097)
- Patrick J. Parsons (ORCID: https://orcid.org/0000-0001-9133-875X)
- Yingying Xu (ORCID: https://orcid.org/0000-0003-2931-1016)
- George D. Papandonatos (ORCID: https://orcid.org/0000-0001-6770-932X)
- Bruce P. Lanphear (ORCID: https://orcid.org/0000-0003-2598-5574)
- Aimin Chen (ORCID: https://orcid.org/0000-0001-9713-6438)
- Joseph M. Braun (ORCID: https://orcid.org/0000-0002-5239-3235)
- Aimée Vester
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- New York State Department of Health (US)
- Wadsworth Center (US)
- Simon Fraser University (CA)
- Brown University (US)
- Albany College of Pharmacy and Health Sciences (US)
- University of Cincinnati (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Environmental Health
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s12940-025-01244-w
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00