Une approche analytique innovante pour un aperçu exhaustif de l'exposition interne humaine aux pesticides
Human exposure to contaminants, including pesticides, is generally estimated using indirect methods. Conventionalbiomonitoring methods remain focused on a limited number of known substances, leaving the risks associated withmultiple exposures currently underexplored.We propose an innovative approach to detect as many pesticide exposure markers as possible in an untargetedmanner by combining three complementary mass spectrometry platforms coupled with chromatography. Thisapproach, based on the exposome concept (Wild, David), allows us to produce exposure data on a wide range ofpesticides and metabolites by screening a broad panel of exposure markers. The results demonstrate the addedvalue of this approach, applied to two epidemiological studies (PELAGIE and Nutrinet-Santé), to test forassociations with health parameters.
Authors
- Emmanuelle Kesse‐Guyot (ORCID: https://orcid.org/0000-0002-9715-3534)
- Tarek Moufawad (ORCID: https://orcid.org/0000-0002-2684-9868)
- Fatima‐Zahra Alem (ORCID: https://orcid.org/0000-0001-5716-4653)
- Laurent Debrauwer (ORCID: https://orcid.org/0000-0003-3600-0902)
- Cécile Chevrier (ORCID: https://orcid.org/0000-0003-3101-8222)
- Mohamed N. Triba
- Arthur David (ORCID: https://orcid.org/0000-0001-8189-1826)
- Emmanuelle Bichon (ORCID: https://orcid.org/0000-0001-7731-8808)
- Julia Baudry
- Emilien L. Jamin (ORCID: https://orcid.org/0000-0002-4568-9177)
- Jean‐Philippe Antignac (ORCID: https://orcid.org/0000-0001-9512-9314)
- Ingrid Guiffard (ORCID: https://orcid.org/0000-0002-6701-1682)
- Nathalie Costet (ORCID: https://orcid.org/0000-0002-3706-4812)
- Elodie Mirmont (ORCID: https://orcid.org/0000-0002-3237-2015)
- Houssein Zhour
- Jean-Marie Savignac
Institutions
- École des Hautes Études en Santé Publique (FR)
- Université Sorbonne Paris Nord (FR)
- Laboratoire D'étude des Résidus et Contaminants Dans les Aliments (FR)
- Toxicologie Alimentaire (FR)
- Institut de Recherche en Santé, Environnement et Travail (FR)
- Biomatériaux et Bioingénierie (FR)
- Centre de Recherche Épidémiologie et Statistique (FR)
- Université de Rennes (FR)
Publication Details
- Journal
- SPIRE - Sciences Po Institutional REpository
- Published
- 2025-08-20
- DOI
- https://doi.org/10.17180/ciag-2025-vol105-art02
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00