Decoding drug tolerance: insights into the Rv0274 gene's role in isoniazid tolerance
Our results suggest that <i>Rv0274</i> (<i>MSMEG_0608</i>) negatively regulates genes linked to <i>Rv0273c</i> (<i>MSMEG_0606</i>), thereby contributing to alterations in inhA expression and influencing isoniazid tolerance. This work provides preliminary mechanistic insight into INH tolerance in mycobacteria and establishes a foundation for further investigations into drug tolerance in <i>Mycobacterium tuberculosis</i>.
Authors
- Zhou Liu
- Wenwen Chu (ORCID: https://orcid.org/0000-0002-0110-806X)
- Qiang Zhou (ORCID: https://orcid.org/0000-0002-9661-3746)
- Min Li (ORCID: https://orcid.org/0000-0003-1330-2326)
- Xiaohong Xiang (ORCID: https://orcid.org/0000-0002-9020-9187)
- Yun Wang (ORCID: https://orcid.org/0000-0002-4749-2984)
- Qiming Li (ORCID: https://orcid.org/0000-0003-4183-9913)
- Lingling Dong
- Zhen Gong (ORCID: https://orcid.org/0000-0001-8141-1087)
- Ye Naifang
Institutions
- Anhui Medical University (CN)
- Karolinska Institutet (SE)
- Anhui Provincial Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Anhui Mental Health Center (CN)
- First Affiliated Hospital of Henan University (CN)
- Chongqing Medical and Pharmaceutical College (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fmicb.2025.1697416
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00