Leukocyte mRNA sequencing reveals unfolded protein response activation in severe heat stroke in Japan
Severe heat stroke in Japanese patients was associated with widespread changes in RNA expression, highlighting activation of the endoplasmic reticulum stress response. These findings provide new insights into the pathophysiology of heat stroke and suggest that targeting cellular stress pathways may be a potential therapeutic approach. Further research is needed to validate these results in larger cohorts and assess their clinical implications.
Authors
- Daisuke Okuzaki (ORCID: https://orcid.org/0000-0002-4552-783X)
- Jun Oda (ORCID: https://orcid.org/0000-0002-8254-3716)
- Hiroshi Ogura (ORCID: https://orcid.org/0000-0002-5013-2445)
- Yusuke Nomura (ORCID: https://orcid.org/0000-0003-4956-562X)
- Hisatake Matsumoto (ORCID: https://orcid.org/0000-0001-5771-570X)
- Junya Shimazaki (ORCID: https://orcid.org/0000-0003-3004-3127)
- Yuki Togami
- Sayaka Oda
Institutions
- Osaka Gakuin University (JP)
- Osaka National Hospital (JP)
- Yokohama City University Hospital (JP)
- Yokohama City University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fcell.2025.1640477
- Primary Topic
- Thermoregulation and physiological responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science