Case Report: A pharmacist-led precision therapy framework for managing invasive fungal infection in CSF1R-Related leukoencephalopathy post Allo-HSCT
This case demonstrates the complexity of managing IFD in CSF1R-related disorder patients after HSCT. The interplay between systemic immunosuppression and intrinsic microglial dysfunction may heighten infection susceptibility. Precision antifungal therapy guided by multidisciplinary team expertise and pharmacological monitoring may improve outcomes in this rare and high-risk population.
Authors
- Yao Fu (ORCID: https://orcid.org/0000-0002-3389-8211)
- Cheng Guo (ORCID: https://orcid.org/0000-0002-0762-8496)
- Zhongqiu Zhang
- Li Hua Cao (ORCID: https://orcid.org/0000-0003-1742-9877)
- Xincai Zhao (ORCID: https://orcid.org/0000-0001-7713-4339)
- Xinghua Luan (ORCID: https://orcid.org/0000-0001-6683-5105)
- Jinmiao Lu (ORCID: https://orcid.org/0000-0001-8411-2111)
- M Jia (ORCID: https://orcid.org/0000-0002-1443-0437)
- Quanjun Yang (ORCID: https://orcid.org/0000-0003-0279-8784)
- Miaomiao Zhou (ORCID: https://orcid.org/0000-0001-6114-8947)
- Li Yang (ORCID: https://orcid.org/0000-0002-8611-6359)
- Jianping Zhang (ORCID: https://orcid.org/0000-0002-1929-792X)
- Jingying Wu (ORCID: https://orcid.org/0000-0002-2192-7599)
- Xiaojun Huang (ORCID: https://orcid.org/0000-0002-3284-8191)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai First People's Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fphar.2025.1656503
- Primary Topic
- Neurological Complications and Syndromes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University