Unveiling the novel value of TREM1 in the proneural-mesenchymal transition of glioma via tumor-associated macrophages
TREM1 functions as an oncogenic biomarker in TAMs that drives GBM PMT via the TLR4/PI3K/AKT/mTOR axis, with inhibition of TREM1 demonstrating therapeutic potential in both ex vivo and <i>in vivo</i> models.
Authors
- Shiqiang Hou (ORCID: https://orcid.org/0000-0002-1694-7202)
- Ning Lin (ORCID: https://orcid.org/0000-0003-0440-4304)
- Chao Wang (ORCID: https://orcid.org/0000-0003-4636-5104)
- Ben Hu (ORCID: https://orcid.org/0009-0001-7648-5695)
- Chao Zhang (ORCID: https://orcid.org/0009-0007-6925-4569)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Chuzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1662351
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00