Identification and validation of key biomarkers of the glycolysis-ketone body metabolism in heart failure based on multi-omics and machine learning
This study identifies TIMP1 as a central regulator linking glycolysis-ketone metabolic imbalance with immune microenvironment dysregulation in heart failure. These findings offer new mechanistic insights and propose TIMP1 as a potential diagnostic biomarker and therapeutic target in HF.
Authors
- Xiaoyong Geng (ORCID: https://orcid.org/0000-0002-2060-5133)
- Jing Liu (ORCID: https://orcid.org/0000-0002-3588-2969)
- Zhe Chen (ORCID: https://orcid.org/0000-0002-1427-8770)
- Na Xiao (ORCID: https://orcid.org/0000-0001-9911-3352)
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fcvm.2025.1672513
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00