Functional and phenotypic analysis of CD4 T cell dynamics in peripheral blood of human visceral leishmaniasis patients confers increased frequencies of CD25 expressing regulatory T cells that contribute to disease pathogenesis
The present study characterizes the frequency, phenotype and function of CD4<sup>+</sup>CD127<sup>-/low</sup>CD25<sup>high</sup>Treg cells of kala-azar patients <i>ex vivo</i>. Our results suggest that functional effector Treg subpopulation elevated during active VL modulate effectors of immune response and induce immunosuppression. These together with naïve and non-Tregs cells constitute a defining feature of VL pathogenesis.
Authors
- George Banik
- Mohammad Asad (ORCID: https://orcid.org/0000-0003-3078-200X)
- Major Madhukar (ORCID: https://orcid.org/0000-0003-3609-9797)
- Mohd Kamran (ORCID: https://orcid.org/0000-0001-9007-6735)
- Krishna Pandey (ORCID: https://orcid.org/0000-0001-5930-2458)
- Sonali Chaudhury (ORCID: https://orcid.org/0000-0001-9816-5126)
- Sarfaraz Ahmad Ejazi (ORCID: https://orcid.org/0000-0001-7312-1549)
- Mehebubar Rahman
- Nahid Ali (ORCID: https://orcid.org/0000-0002-6166-3778)
- Pradyot Bhattacharya
- Smriti Ghosh
- Rama Prosad Goswami
Institutions
- Rajendra Memorial Research Institute of Medical Sciences (IN)
- Indian Institute of Chemical Biology (IN)
- TCG Lifesciences (India) (IN)
- Hospital for Tropical Diseases (VN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1676937
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- UK Research and Innovation
- Indian Council of Medical Research
- Council of Scientific and Industrial Research, India