NLRP3 regulates epithelial barrier integrity and protects from airway hyperresponsiveness in experimental allergic asthma
NLRP3 is essential for epithelial barrier integrity in the lung and protects from the development of allergic asthma in a murine model.
Authors
- Wolfgang Greiner (ORCID: https://orcid.org/0000-0001-9552-6969)
- Stephanie Tamm
- Dominik Funken (ORCID: https://orcid.org/0000-0001-7232-7828)
- Frauke Stanke (ORCID: https://orcid.org/0000-0002-6186-0149)
- Ruth Grychtol (ORCID: https://orcid.org/0000-0002-8084-104X)
- Kirsten Beyer (ORCID: https://orcid.org/0000-0003-1859-0419)
- Stephanie DeStefano
- Erika von Mutius (ORCID: https://orcid.org/0000-0002-8893-4515)
- Bianca Schaub (ORCID: https://orcid.org/0000-0003-1652-8873)
- Eckard Hamelmann (ORCID: https://orcid.org/0000-0002-2996-8248)
- Michael Kabesch (ORCID: https://orcid.org/0000-0003-0697-1871)
- Adan Chari Jirmo (ORCID: https://orcid.org/0000-0002-4693-0081)
- Anika Habener
- Gesine Hansen
Institutions
- Bielefeld University (DE)
- Hochschule Bielefeld (DE)
- Center for Environmental Health (US)
- Helmholtz Zentrum München (DE)
- University Hospital Regensburg (DE)
- Medizinische Hochschule Hannover (DE)
- Humboldt-Universität zu Berlin (DE)
- German Center for Pediatric and Adolescent Rheumatology (DE)
- Evangelisches Krankenhaus Bielefeld (DE)
- German Center for Lung Research (DE)
- Ludwig-Maximilians-Universität München (DE)
- Deutsche Forschungsgemeinschaft (DE)
- Bethel University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1655205
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16