Association between Klotho levels in cerebrospinal fluid and choroid plexus enlargement in neurodegeneration
In this preliminary study, we observed a strong association between CSF Klotho levels and CP enlargement. Reduced CSF Klotho levels, due to CP dysfunction, may contribute to neurodegeneration. If confirmed in larger cohorts, this association suggests that CSF Klotho may serve as a biomarker for CP enlargement, possibly reflecting its underlying dysfunction.
Authors
- Manuela Pintus (ORCID: https://orcid.org/0000-0003-1994-2682)
- Lia Schmid
- Andrea Arighi (ORCID: https://orcid.org/0000-0003-2865-3970)
- María Serpente (ORCID: https://orcid.org/0000-0003-0725-1403)
- Laura Ghezzi (ORCID: https://orcid.org/0000-0001-8180-9730)
- Raffaella Lanzarotti (ORCID: https://orcid.org/0000-0002-8534-4413)
- Marina Arcaro (ORCID: https://orcid.org/0000-0002-3821-0682)
- Anna Margherita Pietroboni (ORCID: https://orcid.org/0000-0003-1538-1830)
- Claudia Dolci (ORCID: https://orcid.org/0000-0002-3060-4097)
- Luca Sacchi (ORCID: https://orcid.org/0000-0002-3929-9009)
- Chiara Fenoglio (ORCID: https://orcid.org/0000-0001-6332-4721)
- Giorgio Conte (ORCID: https://orcid.org/0000-0002-1562-7389)
- Fabio Maria Triulzi (ORCID: https://orcid.org/0000-0002-5428-7217)
- Tiziana Carandini (ORCID: https://orcid.org/0000-0002-0568-7580)
- Daniela Galimberti
- Giorgio Bocca (ORCID: https://orcid.org/0009-0005-3728-9383)
Institutions
- University of Milan (IT)
- Heidelberg University (DE)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fnagi.2025.1688996
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute