IFN-γ induced the formation of foamy macrophages via CD40 signal to control Mycobacterium abscessus pulmonary infection
This study established the IFN-γ-CD40-DGAT1 axis as an important role in the formation of FMs and the control of <i>M. abscessus</i> infection. These findings revealed a critical immune-metabolic pathway that may be leveraged for host-directed therapeutic interventions.
Authors
- Zhenhui Lu (ORCID: https://orcid.org/0000-0002-7172-6621)
- Yu‐Jih Su (ORCID: https://orcid.org/0000-0002-7274-3458)
- Huiyong Zhang (ORCID: https://orcid.org/0000-0002-1982-8137)
- Dingzhong Wu
- Wei Sha (ORCID: https://orcid.org/0009-0005-6653-7817)
- Tian Li (ORCID: https://orcid.org/0000-0002-1996-9001)
- Jiajun Chen (ORCID: https://orcid.org/0000-0003-2534-6633)
- Feng Ya (ORCID: https://orcid.org/0009-0001-6711-864X)
- Xianwei Wu
- Lei Qiu (ORCID: https://orcid.org/0000-0003-2956-2528)
- Shaoyan Zhang (ORCID: https://orcid.org/0000-0002-9563-2873)
- Xing Huang (ORCID: https://orcid.org/0000-0001-7321-8244)
- Hai Lou
- Liping Wang (ORCID: https://orcid.org/0000-0001-9355-1167)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1697443
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00