Biotransformation and kinetics of selected benzimidazole synthetic opioids in human hepatocytes

Nitazenes are susceptible to hepatic metabolism through hydroxylation, <i>N</i>-dealkylation, and conjugation. The extrapolated <i>in vivo</i> metabolic clearance is similar to that of 7-hydroxycoumarin and testosterone. For practical purposes, these findings can provide useful estimations in clinical toxicology and forensic pathology.