Photodynamic therapy with a novel photosensitizer inhibits BLM-induced pulmonary fibrosis in mice via MRC1-mediated pathway
PDT-LD4 exerts anti-fibrotic effects in bleomycin-induced pulmonary fibrosis through multiple mechanisms including anti-inflammation, anti-oxidation and anti-fibrosis, which may be related to the regulation of <i>MRC1</i>. Given its proven efficacy and good safety, PDT-LD4 emerges as a promising novel therapeutic strategy and is worthy of further clinical research for pulmonary fibrosis.
Authors
- Yumei Rong (ORCID: https://orcid.org/0000-0003-2998-005X)
- Minghui Zhu
- Nan Wang (ORCID: https://orcid.org/0009-0006-1132-8054)
- Zhenyu Zhao (ORCID: https://orcid.org/0000-0003-3574-8724)
- Feiyu Zhang (ORCID: https://orcid.org/0009-0005-3071-2265)
Institutions
- Tianjin Third Central Hospital (CN)
- Tianjin Infectious Diseases Hospital (CN)
- Tianjin International Joint Academy of Biomedicine (CN)
- Tianjin Fire Research Institute (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fphar.2025.1714450
- Citations
- 1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52