Disproportionality analysis of taste disorders using the FDA adverse event reporting system and Japanese adverse drug event report databases

Of the 130 drugs for which a signal was detected in both ROR and BCPNN in the FAERS database, 14 had similar signals in the JADER database. Onset time and logistic regression analyses were performed using the FAERS database to characterize drug-induced taste disorders. The median onset time was the same day of administration for nirmatrelvir/ritonavir and clarithromycin; otherwise, it varied among the other drugs. The hazard for clarithromycin remained constant throughout administration, while the hazards for the other drugs decreased over time. Logistic regression analysis confirmed significant associations between the drugs and taste disorders, even after adjusting for age and sex. Overall, these results indicate that certain drugs may be involved in taste disorders, which, depending on their characteristics, warrants further caution and attention. The findings of this study may help healthcare providers recognize drug-induced taste disorders that can lead to a reduced quality of life and noncompliance with medication.