Cardiac structure and inflammation drive memory impairment via dual pathways of heart-brain axis dysregulation in atrial fibrillation patients undergoing catheter ablation
Cardiac structural parameters (LVDd) associate with memory-related brain atrophy, whereas blood-borne inflammatory markers link to hippocampal memory network dysregulation-two distinct pathways driving AF-related memory impairment. These findings clarify the dual-pathway regulatory mechanism of the heart-brain axis, offering novel insights into AF-associated cognitive dysfunction and potential CA-mediated memory recovery.
Authors
- Ming Li (ORCID: https://orcid.org/0000-0001-5173-1602)
- Jiu Chen (ORCID: https://orcid.org/0000-0001-8185-8575)
- Dandan Kou
- Jie Ni (ORCID: https://orcid.org/0000-0002-8844-6132)
- Yu Wang (ORCID: https://orcid.org/0009-0005-9856-9979)
- Yingming Zhao
- Xin Chen (ORCID: https://orcid.org/0000-0002-8775-3376)
- Xiaobo Xue
- Danni Ge
- Biao Xu
Institutions
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fnins.2025.1725953
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province
- Nanjing University
- Nanjing Drum Tower Hospital