Shaoyao gancao decoction induces autophagy by modulating miR-21 and inhibiting the AKT/mTOR signaling pathway in adenomyosis-derived ectopic endometrial stromal cells
The progression of AM is associated with autophagy inhibition in ectopic lesions. SGD can exert autophagy-promoting and pro-apoptotic effects in EESCs, and this process occurs by inhibiting the AKT/mTOR signaling pathway with miR-21 as the target. These findings unveil the potential novel molecular mechanisms from the perspective of microRNA by which SGD suppresses the growth of EESCs.
Authors
- Yuyan Zeng
- Hong‐Shiee Lai (ORCID: https://orcid.org/0000-0002-7958-2183)
- Jie Lu (ORCID: https://orcid.org/0000-0002-0749-5072)
- Jinjin Jia
- Zijun Kuang
Institutions
- Qinghai University (CN)
- Guangzhou University of Chinese Medicine (CN)
- First People's Hospital of Foshan (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fphar.2025.1665911
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- National Natural Science Foundation of China
- Young Scientists Fund