Evaluation of the safety and efficacy of Sophorae Flavescentis Radix extract in the treatment of inflammatory bowel disease based on zebrafish models
Supra-therapeutic doses of Kushen extract can induce marked liver damage in zebrafish. However, when administration within an appropriate dosage range, it does not elicit significant toxicity and demonstrates substantial therapeutic efficacy against IBD, partly through modulating mucosal immunity. These findings provide crucial experimental evidence to support the guidance for safe and rational clinical application of Kushen extract.
Authors
- Zhiqiang Ma (ORCID: https://orcid.org/0000-0002-5555-2764)
- Zhuo Yang (ORCID: https://orcid.org/0000-0001-5212-0053)
- Chongjun Zhao
- Qiqi Fan (ORCID: https://orcid.org/0000-0002-6386-491X)
- Linzhen Chen
- Jiaqi Li (ORCID: https://orcid.org/0000-0002-3716-2543)
- Qi Chen (ORCID: https://orcid.org/0000-0001-5971-7872)
- Xiaolu Chen (ORCID: https://orcid.org/0000-0001-8027-9571)
- Lin Rui-chao (ORCID: https://orcid.org/0000-0003-0670-4298)
- Yuhan Sheng
- Maochang Cui (ORCID: https://orcid.org/0009-0002-7439-4893)
Institutions
- Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1722777
- Citations
- 1
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.81