Restoring <i>Muribaculum intestinale</i> –Derived Butyrate Mitigates Skeletal Muscle Loss in Cancer Cachexia
In cachectic mouse models, Muribaculaceae and Muribaculum intestinale are reduced and exhibit a significant positive correlation with SCFA butyrate. Inulin or MI supplementation increased these bacteria, ameliorating cachexia. NaB attenuates muscle wasting through coordinated modulation of autophagy suppression, anti-inflammatory effects and metabolic reprogramming (including PDK4 downregulation and ATP elevation), collectively indicating the existence of a gut-muscle axis in cachexia progression. These findings underscore the potential of microbiota-targeted interventions in managing cancer cachexia and highlight the intricate interplay between gut microbiota and skeletal muscle health.
Authors
- Wenyuan Pu (ORCID: https://orcid.org/0000-0003-4955-4947)
- Shiyu Song (ORCID: https://orcid.org/0000-0001-8438-2277)
- Junaid Wazir (ORCID: https://orcid.org/0000-0001-9299-4716)
- Chao Ding (ORCID: https://orcid.org/0000-0002-5876-6813)
- Panpan Lian
- Kai Lin (ORCID: https://orcid.org/0000-0003-4927-6094)
- Renwei Lu
- Zhiqiang Huang (ORCID: https://orcid.org/0000-0001-9617-7537)
- Hongwei Wang (ORCID: https://orcid.org/0000-0003-2868-5112)
- Yong Wang (ORCID: https://orcid.org/0000-0001-8366-7887)
- Ranran Wang (ORCID: https://orcid.org/0009-0000-7968-7834)
- Dong Wei (ORCID: https://orcid.org/0000-0002-0973-644X)
- Li Li (ORCID: https://orcid.org/0009-0003-8984-8373)
- Zhenghong Yu
Institutions
- Nanjing General Hospital of Nanjing Military Command (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing Hydraulic Research Institute (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1002/jcsm.70140
- Citations
- 3
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42