HPV status shapes T-cell immunoprofiles in oesophageal adenocarcinoma: high regulatory T cell infiltration predicts poor prognosis
We report novel evidence of an immunoregulatory TME in HPV-negative OAC, as indicated by high Treg proportions and low CD8+:Treg ratios. Future work may lead to improved risk stratification by the presence or absence of HPV, as well as utilising the CD8+:Treg ratio in the local TME as a predictive biomarker. Additionally, a more in-depth understanding of the TME would assist in the development of novel targeted immunotherapies, for example by modulating Tregs or CD8+ T-cells.
Authors
- Rehana Hewavisenti (ORCID: https://orcid.org/0000-0002-0800-516X)
- Mahtab Farzin
- Shanmugarajah Rajendra (ORCID: https://orcid.org/0000-0002-8893-4638)
- Anthony Dominic Kelleher (ORCID: https://orcid.org/0000-0002-0009-3337)
- Sarah Christina Sasson (ORCID: https://orcid.org/0000-0002-5329-9072)
- Mohammad Rabiei (ORCID: https://orcid.org/0000-0002-5430-3846)
- Subin Wui
Institutions
- Camden and Campbelltown Hospitals (AU)
- Bankstown Lidcombe Hospital (AU)
- Liverpool Hospital (AU)
- UNSW Sydney (AU)
- Ingham Institute (AU)
- Western Sydney University (AU)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s12967-025-07482-3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00