Leptin From Fibro‐Adipogenic Progenitor Cells (FAPs) Regulates Masseter Muscle Disuse Atrophy and Ectopic Fat Accumulation
Disuse atrophy reduces leptin secreted by FAPs, triggering lipid accumulation that exacerbates muscle degeneration. This reveals the critical regulatory role of FAPs in maintaining masseter muscle homeostasis through leptin-mediated mechanisms.
Authors
- Xinyi Song (ORCID: https://orcid.org/0000-0002-5062-0756)
- Hong Yongfeng
- Keke Zhang (ORCID: https://orcid.org/0000-0002-5755-7059)
- Ang Gao (ORCID: https://orcid.org/0000-0002-8256-7160)
- Tingting Li (ORCID: https://orcid.org/0000-0002-6113-1624)
- Xiaoyu Liu (ORCID: https://orcid.org/0000-0002-3485-0885)
- Wei Liu (ORCID: https://orcid.org/0000-0002-8033-4718)
- Yan Hao (ORCID: https://orcid.org/0000-0003-3342-2114)
- Tingting Wu (ORCID: https://orcid.org/0000-0003-4375-6820)
- Yi Chen (ORCID: https://orcid.org/0000-0002-3054-0839)
- Qingchun Li (ORCID: https://orcid.org/0009-0000-3273-0487)
- Yu-he Cheng
- Wang Yuan-yin
Institutions
- Anhui Medical University (CN)
- People's Liberation Army 401 Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1002/jcsm.70141
- Citations
- 2
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61