No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study
Our findings suggest that commonly used HC methods do not result in immunologic changes that increase HIV acquisition risk. However, HIV infection enhancement with post-HC CVL <i>in vitro</i> warrants further study.
Authors
- Sakthivel Govindaraj (ORCID: https://orcid.org/0000-0001-5764-6142)
- C. Christina Mehta (ORCID: https://orcid.org/0000-0001-6854-7983)
- Betsy C. Herold (ORCID: https://orcid.org/0000-0001-9974-0786)
- Tyree Staple
- Vijayakumar Velu (ORCID: https://orcid.org/0000-0003-4238-1924)
- Chris Ibegbu
- Gina Bailey Herring (ORCID: https://orcid.org/0000-0002-2306-1194)
- Alicia K. Smith (ORCID: https://orcid.org/0000-0002-8537-5156)
- M. R. Young (ORCID: https://orcid.org/0000-0002-9140-5868)
- Lisa B. Haddad (ORCID: https://orcid.org/0000-0002-7631-6760)
Institutions
- Albert Einstein College of Medicine (US)
- Emory University (US)
- Emory and Henry College (US)
- Grady Health System (US)
- Population Council (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1655678
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development