Location and aetiology are determinants of fibroblast activation and heterogeneity in the failing human heart
These findings provide a comprehensive framework for understanding fibroblast dynamics, highlighting the heterogeneity and spatial complexity of fibrosis in human end-stage HF, and offering potential therapeutic targets to mitigate fibrosis while preserving scar integrity.
Authors
- Samaneh Ekhteraei‐Tousi (ORCID: https://orcid.org/0000-0002-8123-8058)
- Rosa Doñate Puertas (ORCID: https://orcid.org/0000-0002-9230-6765)
- H. Llewelyn Roderick (ORCID: https://orcid.org/0000-0001-7065-3523)
- Karin R. Sipido (ORCID: https://orcid.org/0000-0001-9609-5507)
- Chandan K. Nagaraju (ORCID: https://orcid.org/0000-0002-8409-5478)
- Filip Rega (ORCID: https://orcid.org/0000-0002-8428-2302)
- Bernard Thienpont (ORCID: https://orcid.org/0000-0002-8772-6845)
- Mohamad Youness (ORCID: https://orcid.org/0000-0002-1159-4268)
Institutions
- Center for Human Genetics (US)
- VIB-KU Leuven Center for Microbiology (BE)
- Hasselt University (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s13073-025-01580-z
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00