Efficacy, toxicity, and clinical outcomes of 177Lu-PSMA-617 radioligand therapy at 5.5 GBq per cycle in patients with advanced castration-resistant prostate cancer: a prospective, single arm, phase II study
<sup>177</sup>Lu-PSMA-617 at 5.5 GBq per cycle was safe and effective, achieving survival comparable to studies using 7.4 GBq with fewer severe toxicities. Tailored regimens may benefit patients at higher toxicity risk. These data support further studies to optimize dosage, timing, sequencing and combinations of RLT.
Authors
- Manuela Monti (ORCID: https://orcid.org/0000-0002-3587-1768)
- Irene Marini (ORCID: https://orcid.org/0009-0002-6186-688X)
- Erika Giani
- Valentina Di Iorio (ORCID: https://orcid.org/0000-0002-5380-6185)
- Ilaria Grassi (ORCID: https://orcid.org/0000-0002-9566-7670)
- Stefano Severi (ORCID: https://orcid.org/0000-0003-1846-0681)
- Silvia Nicolini (ORCID: https://orcid.org/0000-0002-3960-7737)
- Anna Sarnelli (ORCID: https://orcid.org/0000-0001-5986-3845)
- Maddalena Sansovini (ORCID: https://orcid.org/0000-0002-7699-262X)
- Federica Matteucci (ORCID: https://orcid.org/0000-0001-7455-6253)
- Giovanni Paganelli (ORCID: https://orcid.org/0000-0002-2631-4652)
- Francesca Borgia (ORCID: https://orcid.org/0000-0002-9753-9699)
- Ugo De Giorgi (ORCID: https://orcid.org/0000-0001-7520-2908)
- Flavia Foca (ORCID: https://orcid.org/0000-0002-5529-4769)
- Monica Celli (ORCID: https://orcid.org/0000-0002-0338-800X)
- Emilio Francesco Giunta (ORCID: https://orcid.org/0000-0002-5383-4469)
- Lilla Vizza (ORCID: https://orcid.org/0009-0002-7734-3426)
Institutions
- University of Ferrara (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1007/s00259-025-07661-w
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute