Copper-Mediated Radical Cyclopropanation of Activated Alkenes under Continuous-Flow Conditions
Polysubstituted cyclopropanes are valuable in complex molecule synthesis but challenging to access due to low atom economy and harsh conditions. Herein, we report a copper-mediated, peroxide-initiated cyclopropanation of activated alkenes with active methylene compounds via a radical pathway. This diazo-free, prefunctionalization-free method, integrated with continuous flow, enhances safety, scalability, and efficiency. Operable under mild conditions with broad substrate scope, it offers a practical and atom-economical route to diverse polysubstituted cyclopropanes.
Authors
- Zheng Fang (ORCID: https://orcid.org/0000-0002-3209-4713)
- Quanxiao Dong
- Changhai Yue
- Jianping Fu (ORCID: https://orcid.org/0000-0001-9629-6739)
- Rui Luo (ORCID: https://orcid.org/0000-0002-8465-2510)
- Peng Qiu (ORCID: https://orcid.org/0000-0002-1076-5985)
- Feng Chen (ORCID: https://orcid.org/0000-0002-3637-4771)
- Yuguang Li (ORCID: https://orcid.org/0000-0002-9559-7051)
- Yiping Huang (ORCID: https://orcid.org/0000-0003-2353-5561)
- Hong Qin (ORCID: https://orcid.org/0009-0006-5607-0712)
Institutions
- Nanjing Tech University (CN)
- Qingdao Installation & Construction (China) (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Materials Technology (United Kingdom) (GB)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1021/acs.joc.5c02327
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00