Semaphorin 5A modulates focal adhesion pathway and lamellipodia formation in melanoma
These findings establish for the first time that SEMA5A is a novel player of melanoma aggressiveness and progression, modulating cancer cell viability and migration, focal adhesion signaling and lamellipodia formation in vitro and tumor growth in vivo.
Authors
- Aldo Palange
- Piero Del Boccio (ORCID: https://orcid.org/0000-0003-1653-2194)
- Marta Di Martile (ORCID: https://orcid.org/0000-0001-9924-9022)
- Luca Tamagnone (ORCID: https://orcid.org/0000-0002-2884-7946)
- Elisabetta Valentini (ORCID: https://orcid.org/0000-0003-3073-3590)
- Simona D’Aguanno (ORCID: https://orcid.org/0000-0002-1224-4454)
- Maria Concetta Cufaro (ORCID: https://orcid.org/0000-0002-6457-7795)
- Cristiana Ercolani (ORCID: https://orcid.org/0000-0003-0131-7766)
- Donatella Del Bufalo (ORCID: https://orcid.org/0000-0002-3148-6096)
- Ilenia Masi (ORCID: https://orcid.org/0000-0001-8927-1998)
- Matteo Brignone
- Laura Rosanò (ORCID: https://orcid.org/0000-0002-9962-6411)
- Fabio Di Ferdinando
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Chieti-Pescara (IT)
- Institute of Molecular Biology and Pathology (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s12964-025-02526-z
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondazione Italiana per la Ricerca sul Cancro