Exploring the mechanisms of protective effect of high-energy X-ray FLASH radiotherapy on intestine through multi omics analysis
This study confirms that FLASH-RT, compared to CONV-RT, maintains equivalent antitumor efficacy while mitigating damage to normal intestinal tissues. Moreover, it preliminarily reveals that the protective mechanism of FLASH-RT is multifaceted, involving remodeling of the microbiota-metabolite axis, attenuation of inflammatory responses, and enhanced preservation of stem cells.
Authors
- Mingming Tang (ORCID: https://orcid.org/0000-0002-3157-4803)
- Xiaobo Du (ORCID: https://orcid.org/0000-0001-6348-0636)
- Yihan Zhu (ORCID: https://orcid.org/0000-0002-8150-7350)
- Wenqiang Tang (ORCID: https://orcid.org/0000-0002-2972-5748)
- Huan Du (ORCID: https://orcid.org/0000-0002-0020-149X)
- Yiwei Yang (ORCID: https://orcid.org/0000-0002-3885-2976)
- Jie Li (ORCID: https://orcid.org/0000-0002-4974-6116)
- Wei Wu (ORCID: https://orcid.org/0000-0002-3137-4086)
- Haonan Xu (ORCID: https://orcid.org/0000-0001-8873-0320)
- Feng Gao (ORCID: https://orcid.org/0000-0001-7456-9767)
- Binwei Lin
- Decai Wang (ORCID: https://orcid.org/0000-0003-2583-5584)
- Yuwen Liang
- Xiaofei Hao
Institutions
- North Sichuan Medical University (CN)
- Southwest University of Science and Technology (CN)
- University of Electronic Science and Technology of China (CN)
- China Academy of Engineering Physics (CN)
- Mianyang Central Hospital (CN)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1186/s13014-025-02763-z
- Citations
- 2
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 2.72