Cell-Free DNA Profiles End-Organ Injury and Predicts Outcomes in Advanced Heart Failure With Left Ventricular Assist Device Implantation
LVAD implantation was associated with reductions in systemic and tissue-specific cfDNA levels. cfDNA levels offer promise for improving risk stratification of LVAD candidates for post-LVAD outcomes.
Authors
- Michael A. Solomon (ORCID: https://orcid.org/0000-0001-7400-6614)
- Hyesik Kong (ORCID: https://orcid.org/0000-0001-7540-2045)
- Palak Shah (ORCID: https://orcid.org/0000-0001-8175-168X)
- T. Andargie (ORCID: https://orcid.org/0000-0003-2888-1316)
- P. Balasubramanian (ORCID: https://orcid.org/0000-0002-0821-1326)
- Woojin Park (ORCID: https://orcid.org/0000-0001-9982-0057)
- Xin Tian (ORCID: https://orcid.org/0000-0003-1896-2462)
- Neelam Redekar (ORCID: https://orcid.org/0000-0002-4819-9034)
- Daniel Tang (ORCID: https://orcid.org/0000-0001-7142-1783)
- Hannah A. Valantine (ORCID: https://orcid.org/0000-0002-2948-9503)
- Tom Hill (ORCID: https://orcid.org/0000-0002-4661-6391)
- Andrew H. Karaba (ORCID: https://orcid.org/0000-0003-2785-317X)
- Sean Agbor-Enoh (ORCID: https://orcid.org/0000-0002-9380-9161)
- Moon Kyoo Jang (ORCID: https://orcid.org/0000-0002-1657-2877)
- Isabella Cavagna (ORCID: https://orcid.org/0009-0003-4968-647X)
- Ashley Park (ORCID: https://orcid.org/0009-0007-8149-2121)
- Xinyue Zhao (ORCID: https://orcid.org/0000-0003-2684-1345)
- Michael Keller (ORCID: https://orcid.org/0000-0002-6695-4582)
Institutions
- National Institutes of Health (US)
- Johns Hopkins University (US)
- Palo Alto University (US)
- George Washington University (US)
- Johns Hopkins Medicine (US)
- Office of the Director (US)
- National Heart, Lung, and Blood Institute (US)
- National Institute of Allergy and Infectious Diseases (US)
- Center for Genomic Science (IT)
- Alaska Heart and Vascular Institute (US)
- National Institutes of Health Clinical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Circulation Heart Failure
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1161/circheartfailure.124.013302
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- NIH Clinical Center
- NHLBI Division of Intramural Research